5DHJ

PIM1 in complex with Cpd4 (3-methyl-5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridine)

Summary for 5DHJ

Entry DOI	10.2210/pdb5dhj/pdb
Related	5DGZ 5DIA
Descriptor	Serine/threonine-protein kinase pim-1, 3-methyl-5-(pyridin-3-yl)-2H-pyrazolo[3,4-c]pyridine, PHOSPHATE ION, ... (4 entities in total)
Functional Keywords	pim-1, kinase, atp-competitive, structure-based drug design, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	1
Total formula weight	34847.32
Authors	Murray, J.M.,Wallweber, H. (deposition date: 2015-08-31, release date: 2015-10-28, Last modification date: 2024-03-06)
Primary citation	Hu, H.,Wang, X.,Chan, G.K.,Chang, J.H.,Do, S.,Drummond, J.,Ebens, A.,Lee, W.,Ly, J.,Lyssikatos, J.P.,Murray, J.,Moffat, J.G.,Chao, Q.,Tsui, V.,Wallweber, H.,Kolesnikov, A. Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors. Bioorg.Med.Chem.Lett., 25:5258-5264, 2015 Cited by PubMed: 26459208 DOI: 10.1016/j.bmcl.2015.09.052 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.457 Å)

Structure validation