5DIA

PIM1 in complex with Cpd36 ((1S,3S)-N1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)cyclohexane-1,3-diamine)

Summary for 5DIA

Entry DOI	10.2210/pdb5dia/pdb
Related	5DGZ 5DHJ
Descriptor	Serine/threonine-protein kinase pim-1, (1S,3S)-N-{6-[5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl]pyridin-2-yl}cyclohexane-1,3-diamine (3 entities in total)
Functional Keywords	pim-1, kinase, atp-competitive, structure-based drug design, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	1
Total formula weight	34832.61
Authors	Murray, J.M.,Wallweber, H. (deposition date: 2015-08-31, release date: 2015-10-28, Last modification date: 2024-03-06)
Primary citation	Hu, H.,Wang, X.,Chan, G.K.,Chang, J.H.,Do, S.,Drummond, J.,Ebens, A.,Lee, W.,Ly, J.,Lyssikatos, J.P.,Murray, J.,Moffat, J.G.,Chao, Q.,Tsui, V.,Wallweber, H.,Kolesnikov, A. Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors. Bioorg.Med.Chem.Lett., 25:5258-5264, 2015 Cited by PubMed: 26459208 DOI: 10.1016/j.bmcl.2015.09.052 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.964 Å)

Structure validation