5DGS
Crystal structure of human FPPS in complex with the monophosphonate compound 15
Summary for 5DGS
Entry DOI | 10.2210/pdb5dgs/pdb |
Related | 5DGM 5DGN |
Descriptor | Farnesyl pyrophosphate synthase, {(E)-2-[6-(acetylamino)-8-(naphthalen-1-yl)quinolin-2-yl]ethenyl}phosphonic acid (3 entities in total) |
Functional Keywords | transferase, isoprene biosynthesis, cholesterol biosynthesis |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P14324 |
Total number of polymer chains | 1 |
Total formula weight | 40602.24 |
Authors | Rondeau, J.M.,Bourgier, E.,Lehmann, S. (deposition date: 2015-08-28, release date: 2016-07-13, Last modification date: 2024-05-08) |
Primary citation | Jahnke, W.,Bold, G.,Marzinzik, A.L.,Ofner, S.,Pelle, X.,Cotesta, S.,Bourgier, E.,Lehmann, S.,Henry, C.,Hemmig, R.,Stauffer, F.,Hartwieg, J.C.,Green, J.R.,Rondeau, J.M. A General Strategy for Targeting Drugs to Bone. Angew.Chem.Int.Ed.Engl., 54:14575-14579, 2015 Cited by PubMed: 26457482DOI: 10.1002/anie.201507064 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.62 Å) |
Structure validation
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