5DEN

The First Structure of a Full-Length Mammalian Phenylalanine Hydroxylase Reveals the Architecture of an Auto-inhibited Tetramer

5DEN の概要

• エントリーDOI: 10.2210/pdb5den/pdb
• 分子名称: Phenylalanine-4-hydroxylase, FE (III) ION (3 entities in total)
• 機能のキーワード: mammalian phenylalanine hydroxylase, allosteric regulation by phenylalanine, phenylketonuria, act-containing, oxidoreductase
• 由来する生物種: Rattus norvegicus (Rat)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 207709.62

構造登録者

Arturo, E.C.,Loll, P.J.,Jaffe, E.K. (登録日: 2015-08-25, 公開日: 2016-02-17, 最終更新日: 2023-09-27)

• 主引用文献: Arturo, E.C.,Gupta, K.,Heroux, A.,Stith, L.,Cross, P.J.,Parker, E.J.,Loll, P.J.,Jaffe, E.K.; First structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramer.; Proc.Natl.Acad.Sci.USA, 113:2394-2399, 2016; PubMed: 26884182; DOI: 10.1073/pnas.1516967113

実験手法

X-RAY DIFFRACTION (2.9 Å)