5D6F

Structure of human methionine aminopeptidase-2 complexed with spiroepoxytriazole inhibitor (+)-31b

Summary for 5D6F

• Entry DOI: 10.2210/pdb5d6f/pdb
• Descriptor: Methionine aminopeptidase 2, (4S,7R)-7-hydroxy-1-(4-methoxybenzyl)-7-methyl-4,5,6,7-tetrahydro-1H-benzotriazol-4-yl propan-2-ylcarbamate, COBALT (II) ION, ... (6 entities in total)
• Functional Keywords: metap2, methionine aminopeptidase-2, inhibitor, spiroepoxytriazole, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 42215.89

Authors

Janowski, R.,Miller, A.K.,Niessing, D. (deposition date: 2015-08-12, release date: 2016-01-13, Last modification date: 2024-01-10)

• Primary citation: Morgen, M.,Jost, C.,Malz, M.,Janowski, R.,Niessing, D.,Klein, C.D.,Gunkel, N.,Miller, A.K.; Spiroepoxytriazoles Are Fumagillin-like Irreversible Inhibitors of MetAP2 with Potent Cellular Activity.; Acs Chem.Biol., 11:1001-1011, 2016; PubMed: 26686773; DOI: 10.1021/acschembio.5b00755

Experimental method

X-RAY DIFFRACTION (1.55 Å)