5D6E

Structure of human methionine aminopeptidase 2 with covalent spiroepoxytriazole inhibitor (-)-31b

5D6E の概要

• エントリーDOI: 10.2210/pdb5d6e/pdb
• 分子名称: Methionine aminopeptidase 2, (4R,7S)-7-hydroxy-1-(4-methoxybenzyl)-7-methyl-4,5,6,7-tetrahydro-1H-benzotriazol-4-yl propan-2-ylcarbamate, COBALT (II) ION, ... (5 entities in total)
• 機能のキーワード: methionine aminopeptidase 2, spiroepoxytriazoles, inhibitor, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42150.69

構造登録者

Janowski, R.,Miller, A.K.,Niessing, D. (登録日: 2015-08-12, 公開日: 2016-01-13, 最終更新日: 2024-01-10)

• 主引用文献: Morgen, M.,Jost, C.,Malz, M.,Janowski, R.,Niessing, D.,Klein, C.D.,Gunkel, N.,Miller, A.K.; Spiroepoxytriazoles Are Fumagillin-like Irreversible Inhibitors of MetAP2 with Potent Cellular Activity.; Acs Chem.Biol., 11:1001-1011, 2016; PubMed: 26686773; DOI: 10.1021/acschembio.5b00755

実験手法

X-RAY DIFFRACTION (1.49 Å)