5D29

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a hydroxamate inhibitor JHU241

Summary for 5D29

Entry DOI	10.2210/pdb5d29/pdb
Descriptor	Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
Functional Keywords	prostate-specific membrane antigen, naaladase, phosphoramidate, hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane ; Single-pass type II membrane protein . Isoform PSMA': Cytoplasm : Q04609
Total number of polymer chains	1
Total formula weight	81370.32
Authors	Barinka, C.,Novakova, Z.,Pavlicek, J. (deposition date: 2015-08-05, release date: 2016-04-27, Last modification date: 2020-07-29)
Primary citation	Novakova, Z.,Wozniak, K.,Jancarik, A.,Rais, R.,Wu, Y.,Pavlicek, J.,Ferraris, D.,Havlinova, B.,Ptacek, J.,Vavra, J.,Hin, N.,Rojas, C.,Majer, P.,Slusher, B.S.,Tsukamoto, T.,Barinka, C. Unprecedented Binding Mode of Hydroxamate-Based Inhibitors of Glutamate Carboxypeptidase II: Structural Characterization and Biological Activity. J.Med.Chem., 59:4539-4550, 2016 Cited by PubMed: 27074627 DOI: 10.1021/acs.jmedchem.5b01806 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation