5D29

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a hydroxamate inhibitor JHU241

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Glutamate carboxypeptidase 2	polymer	695	78341.4	1	UniProt (Q04609) Pfam (PF02225) Pfam (PF04389) Pfam (PF04253)	Homo sapiens (Human)	Cell growth-inhibiting gene 27 protein,Folate hydrolase 1,Folylpoly-gamma-glutamate carboxypeptidase,FGCP,Glutamate carboxypeptidase II,GCPII,Membrane glutamate carboxypeptidase,mGCP,N-acetylated-alpha-linked acidic dipeptidase I,NAALADase I,Prostate-specific membrane antigen,PSMA,Pteroylpoly-gamma-glutamate carboxypeptidase
2	B, C (B, C)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
3	D (D)	beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G31886NL)
4	E, F, G, H (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
5	I, J (A)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
6	K (A)	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
7	L (A)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
8	M (A)	ACETATE ION	non-polymer		59.0	1	Chemie (ACT)
9	N (A)	4-[(2~{S})-2-carboxy-5-(oxidanylamino)-5-oxidanylidene-pentyl]benzoic acid	non-polymer		281.3	1	Chemie (5Q1)
10	O (A)	water	water		18.0	364	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	78341.4
Branched	Number of molecules	3
	Total formula weight	1597.5
Non-Polymers*	Number of molecules	10
	Total formula weight	1431.5
All*	Total formula weight	81370.3

*Water molecules are not included.