5CYM

HIV-1 reverse transcriptase complexed with 4-iodopyrazole

5CYM の概要

• エントリーDOI: 10.2210/pdb5cym/pdb
• 関連するPDBエントリー: 4GIQ 5CW1 5CXR 5CYQ
• 分子名称: HIV-1 reverse transcriptase, p66 subunit, HIV-1 reverse transcriptase, p51 subunit, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ... (9 entities in total)
• 機能のキーワード: 4-bromopyrazole, phasing, influenza endonuclease, fragment screening, transferase
• 由来する生物種: Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1); 詳細
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 118358.83

構造登録者

Bauman, J.D.,Arnold, E. (登録日: 2015-07-30, 公開日: 2015-12-30, 最終更新日: 2024-03-06)

• 主引用文献: Bauman, J.D.,Harrison, J.J.E.K.,Arnold, E.; Rapid experimental SAD phasing and hot spot identification with halogenated fragments; Iucrj, 3:51-60, 2016; DOI: 10.1107/S2052252515021259

実験手法

X-RAY DIFFRACTION (2.1 Å)