5CXV

Structure of the human M1 muscarinic acetylcholine receptor bound to antagonist Tiotropium

5CXV の概要

• エントリーDOI: 10.2210/pdb5cxv/pdb
• 分子名称: Muscarinic acetylcholine receptor M1,Endolysin,Muscarinic acetylcholine receptor M1, FLAG peptide, (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane, ... (8 entities in total)
• 機能のキーワード: acetylcholine, allosteric regulation, carrier proteins, cholinergic antagonists, tiotropium receptor, muscarinic m1, gpcr, subtype selectivity, hydrolase
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P11229
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 60846.89

構造登録者

Sun, B.,Feng, D.,Li, X.,Kobilka, T.S.,Kobilka, B.K. (登録日: 2015-07-29, 公開日: 2016-03-09, 最終更新日: 2016-03-30)

• 主引用文献: Thal, D.M.,Sun, B.,Feng, D.,Nawaratne, V.,Leach, K.,Felder, C.C.,Bures, M.G.,Evans, D.A.,Weis, W.I.,Bachhawat, P.,Kobilka, T.S.,Sexton, P.M.,Kobilka, B.K.,Christopoulos, A.; Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.; Nature, 531:335-340, 2016; PubMed: 26958838; DOI: 10.1038/nature17188

実験手法

X-RAY DIFFRACTION (2.7 Å)