5CXI

Crystal structure of Mycobacterium tuberculosis KstR in complex with 3-oxo-23,24-bisnorchol-4-en-22-oyl-CoA (4-BNC-CoA)

5CXI の概要

• エントリーDOI: 10.2210/pdb5cxi/pdb
• 関連するPDBエントリー: 3MNL 5CW8
• 分子名称: HTH-type transcriptional repressor KstR, 3-oxo-23,24-bisnorchol-4-en-22-oyl-CoA (3 entities in total)
• 機能のキーワード: transcriptional repressor, tetr family tcholesterol catabolism, coa thioester ligand, structural genomics, tb structural genomics consortium, tbsgc, transcription
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 46893.03

構造登録者

Ho, N.A.T.,Dawes, S.,Kendall, S.,Casabon, I.,Crowe, A.M.,Baker, E.N.,Eltis, L.D.,Lott, J.S.,TB Structural Genomics Consortium (TBSGC) (登録日: 2015-07-29, 公開日: 2016-02-17, 最終更新日: 2024-03-06)

• 主引用文献: Ho, N.A.,Dawes, S.S.,Crowe, A.M.,Casabon, I.,Gao, C.,Kendall, S.L.,Baker, E.N.,Eltis, L.D.,Lott, J.S.; The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.; J.Biol.Chem., 291:7256-7266, 2016; PubMed: 26858250; DOI: 10.1074/jbc.M115.707760

実験手法

X-RAY DIFFRACTION (2 Å)