5CTV

Catalytic domain of LytA, the major autolysin of Streptococcus pneumoniae, (C60A, H133A, C136A mutant) complexed with peptidoglycan fragment

Summary for 5CTV

• Entry DOI: 10.2210/pdb5ctv/pdb
• Related: 4IVV
• Descriptor: Autolysin, fragment of peptidoglycan, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-methyl 2-acetamido-3-O-[(1R)-1-carboxyethyl]-2-deoxy-beta-D-glucopyranoside-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-methyl 2-acetamido-3-O-[(1R)-1-carboxyethyl]-2-deoxy-beta-D-glucopyranoside, ... (4 entities in total)
• Functional Keywords: lyta, pneumococci, autolysis, amidase, peptidoglycan complex, antibiotics, hydrolase
• Biological source: Streptococcus pneumoniae serotype 4; More
• Cellular location: Secreted : P06653
• Total number of polymer chains: 3
• Total formula weight: 23181.31

Authors

Achour, A.,Sandalova, T.,Mellroth, P. (deposition date: 2015-07-24, release date: 2016-06-15, Last modification date: 2024-01-10)

• Primary citation: Sandalova, T.,Lee, M.,Henriques-Normark, B.,Hesek, D.,Mobashery, S.,Mellroth, P.,Achour, A.; The crystal structure of the major pneumococcal autolysin LytA in complex with a large peptidoglycan fragment reveals the pivotal role of glycans for lytic activity.; Mol.Microbiol., 101:954-967, 2016; PubMed: 27273793; DOI: 10.1111/mmi.13435

Experimental method

X-RAY DIFFRACTION (1.05 Å)