5CTE

Humanized yeast ACC carboxyltransferase domain bound to 2,2-dimethylpropyl (1S)-1-methyl-8-[(7-methyl-1H-indazol-5-yl)carbonyl]-2,8-diazaspiro[4.5]decane-2-carboxylate

5CTE の概要

• エントリーDOI: 10.2210/pdb5cte/pdb
• 関連するPDBエントリー: 5CTB 5CTC
• 分子名称: Acetyl-CoA carboxylase, 2,2-dimethylpropyl (1S)-1-methyl-8-[(7-methyl-1H-indazol-5-yl)carbonyl]-2,8-diazaspiro[4.5]decane-2-carboxylate, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: acc, inhibitors, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Saccharomyces cerevisiae (Baker's yeast)
• 細胞内の位置: Cytoplasm: Q00955
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 175390.85

構造登録者

Vajdos, F.F. (登録日: 2015-07-23, 公開日: 2015-10-14, 最終更新日: 2024-03-06)

• 主引用文献: Kung, D.W.,Griffith, D.A.,Esler, W.P.,Vajdos, F.F.,Mathiowetz, A.M.,Doran, S.D.,Amor, P.A.,Bagley, S.W.,Banks, T.,Cabral, S.,Ford, K.,Garcia-Irizarry, C.N.,Landis, M.S.,Loomis, K.,McPherson, K.,Niosi, M.,Rockwell, K.L.,Rose, C.,Smith, A.C.,Southers, J.A.,Tapley, S.,Tu, M.,Valentine, J.J.; Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.; Bioorg.Med.Chem.Lett., 25:5352-5356, 2015; PubMed: 26411795; DOI: 10.1016/j.bmcl.2015.09.035

実験手法

X-RAY DIFFRACTION (2.34 Å)