5CSZ

CRYSTAL STRUCTURE OF GANTENERUMAB FAB FRAGMENT IN COMPLEX WITH ABETA 1-11

Summary for 5CSZ

• Entry DOI: 10.2210/pdb5csz/pdb
• Descriptor: GANTENERUMAB FAB FRAGMENT HEAVY CHAIN, GANTENERUMAB FAB FRAGMENT LIGHT CHAIN, Amyloid beta A4 protein, ... (6 entities in total)
• Functional Keywords: antibody, alzheimer, abeta, gantenerumab, gant_abeta_1_11 09-a, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 98421.40

Authors

Benz, J.,Burger, D.,Loetscher, H.R.,Bohrmann, B. (deposition date: 2015-07-23, release date: 2015-08-12, Last modification date: 2020-07-29)

• Primary citation: Bohrmann, B.,Baumann, K.,Benz, J.,Gerber, F.,Huber, W.,Knoflach, F.,Messer, J.,Oroszlan, K.,Rauchenberger, R.,Richter, W.F.,Rothe, C.,Urban, M.,Bardroff, M.,Winter, M.,Nordstedt, C.,Loetscher, H.; Gantenerumab: a novel human anti-Abeta antibody demonstrates sustained cerebral amyloid-Beta binding and elicits cell-mediated removal of human amyloid-Beta.; J. Alzheimers Dis., 28:49-69, 2012; PubMed: 21955818; DOI: 10.3233/JAD-2011-110977

Experimental method

X-RAY DIFFRACTION (1.8 Å)