5CP6

Nucleosome Core Particle with Adducts from the Anticancer Compound, [(eta6-5,8,9,10-tetrahydroanthracene)Ru(ethylenediamine)Cl][PF6]

5CP6 の概要

• エントリーDOI: 10.2210/pdb5cp6/pdb
• 分子名称: DNA (145-MER), Histone H3.2, Histone H4, ... (10 entities in total)
• 機能のキーワード: nucleosome core particle, antitumour compound, structural protein-dna complex, structural protein/dna
• 由来する生物種: Xenopus laevis (African clawed frog); 詳細
• 細胞内の位置: Nucleus: P84233 P62799 P02281
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 199584.29

構造登録者

Ma, Z.,Adhireksan, Z.,Murray, B.S.,Dyson, P.J.,Davey, C.A. (登録日: 2015-07-21, 公開日: 2016-06-01, 最終更新日: 2023-11-08)

• 主引用文献: Ma, Z.,Palermo, G.,Adhireksan, Z.,Murray, B.S.,von Erlach, T.,Dyson, P.J.,Rothlisberger, U.,Davey, C.A.; An Organometallic Compound which Exhibits a DNA Topology-Dependent One-Stranded Intercalation Mode.; Angew.Chem.Int.Ed.Engl., 55:7441-7444, 2016; PubMed: 27184539; DOI: 10.1002/anie.201602145

実験手法

X-RAY DIFFRACTION (2.6 Å)