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5CNJ

mGlur2 with glutamate analog

Summary for 5CNJ
Entry DOI10.2210/pdb5cnj/pdb
Related5CNI
DescriptorMetabotropic glutamate receptor 2, 2-acetamido-2-deoxy-beta-D-glucopyranose, (1R,2S,4R,5R,6R)-2-amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, ... (4 entities in total)
Functional Keywordsglutamate receptor analog, signaling protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight112131.39
Authors
Monn, J.A.,Clawson, D.K. (deposition date: 2015-07-17, release date: 2015-09-09, Last modification date: 2020-07-29)
Primary citationMonn, J.A.,Prieto, L.,Taboada, L.,Hao, J.,Reinhard, M.R.,Henry, S.S.,Beadle, C.D.,Walton, L.,Man, T.,Rudyk, H.,Clark, B.,Tupper, D.,Baker, S.R.,Lamas, C.,Montero, C.,Marcos, A.,Blanco, J.,Bures, M.,Clawson, D.K.,Atwell, S.,Lu, F.,Wang, J.,Russell, M.,Heinz, B.A.,Wang, X.,Carter, J.H.,Getman, B.G.,Catlow, J.T.,Swanson, S.,Johnson, B.G.,Shaw, D.B.,McKinzie, D.L.
Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist.
J.Med.Chem., 58:7526-7548, 2015
Cited by
PubMed: 26313429
DOI: 10.1021/acs.jmedchem.5b01124
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.65 Å)
Structure validation

217705

数据于2024-03-27公开中

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