Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5CNI

mGlu2 with Glutamate

Summary for 5CNI
Entry DOI10.2210/pdb5cni/pdb
Related5CNJ
DescriptorMetabotropic glutamate receptor 2, GLUTAMIC ACID, CHLORIDE ION, ... (6 entities in total)
Functional Keywordsreceptor, glutamate, metabotropic, signaling protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight112721.64
Authors
Clawson, D.K.,Atwell, S.,Monn, J.A. (deposition date: 2015-07-17, release date: 2015-09-09, Last modification date: 2023-02-15)
Primary citationMonn, J.A.,Prieto, L.,Taboada, L.,Hao, J.,Reinhard, M.R.,Henry, S.S.,Beadle, C.D.,Walton, L.,Man, T.,Rudyk, H.,Clark, B.,Tupper, D.,Baker, S.R.,Lamas, C.,Montero, C.,Marcos, A.,Blanco, J.,Bures, M.,Clawson, D.K.,Atwell, S.,Lu, F.,Wang, J.,Russell, M.,Heinz, B.A.,Wang, X.,Carter, J.H.,Getman, B.G.,Catlow, J.T.,Swanson, S.,Johnson, B.G.,Shaw, D.B.,McKinzie, D.L.
Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist.
J.Med.Chem., 58:7526-7548, 2015
Cited by
PubMed: 26313429
DOI: 10.1021/acs.jmedchem.5b01124
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.69 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon