Crystal Structure of MraY in complex with Muraymycin D2

Summary for 5CKR

DescriptorPhospho-N-acetylmuramoyl-pentapeptide-transferase, Muraymycin D2 (3 entities in total)
Functional Keywordsalpha-helical, pnpt superfamily, phospho-murnac-pentapeptide translocase, membrane protein, bacterial cell wall, synthesis, natural product inhibitor, transferase-antibiotic complex, transferase/antibiotic
Biological sourceAquifex aeolicus (strain VF5)
Cellular locationCell inner membrane ; Multi-pass membrane protein  O66465
Total number of polymer chains1
Total molecular weight41870.63
Lee, S.Y.,Chung, B.C.,Mashalidis, E.H.,Tanino, T.,Kim, M.,Hong, J.,Ichikawa, S. (deposition date: 2015-07-15, release date: 2016-03-02, Last modification date: 2017-09-27)
Primary citation
Chung, B.C.,Mashalidis, E.H.,Tanino, T.,Kim, M.,Matsuda, A.,Hong, J.,Ichikawa, S.,Lee, S.Y.
Structural insights into inhibition of lipid I production in bacterial cell wall synthesis.
Nature, 533:557-560, 2016
PubMed: 27088606 (PDB entries with the same primary citation)
DOI: 10.1038/nature17636
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2641801.1%11.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution