5CKA

Human beta-2 microglobulin double mutant W60G-N83V

Summary for 5CKA

• Entry DOI: 10.2210/pdb5cka/pdb
• Related: 2Z9T 5CFH
• Descriptor: Beta-2-microglobulin, GLYCEROL, ACETATE ION, ... (5 entities in total)
• Functional Keywords: aggregation propensity, amyloid, beta-sandwitch, fold stability, immune system
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted : P61769
• Total number of polymer chains: 1
• Total formula weight: 12143.62

Authors

Sala, B.M.,De Rosa, M.,Bolognesi, M.,Ricagno, S. (deposition date: 2015-07-15, release date: 2016-05-18, Last modification date: 2024-01-10)

• Primary citation: Camilloni, C.,Sala, B.M.,Sormanni, P.,Porcari, R.,Corazza, A.,De Rosa, M.,Zanini, S.,Barbiroli, A.,Esposito, G.,Bolognesi, M.,Bellotti, V.,Vendruscolo, M.,Ricagno, S.; Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability.; Sci Rep, 6:25559-25559, 2016; PubMed: 27150430; DOI: 10.1038/srep25559

Experimental method

X-RAY DIFFRACTION (1.7 Å)