5CJO

Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin

5CJO の概要

• エントリーDOI: 10.2210/pdb5cjo/pdb
• 分子名称: Insulin-degrading enzyme, FAB Heavy chain with engineered elbow, FAB light chain, ... (6 entities in total)
• 機能のキーワード: hydrolase, fab, elbow-engineer, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 166314.66

構造登録者

liang, w.g.,bailey, L.,tang, w.j. (登録日: 2015-07-14, 公開日: 2016-07-20, 最終更新日: 2023-09-27)

• 主引用文献: Bailey, L.J.,Sheehy, K.M.,Dominik, P.K.,Liang, W.G.,Rui, H.,Clark, M.,Jaskolowski, M.,Kim, Y.,Deneka, D.,Tang, W.J.,Kossiakoff, A.A.; Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination.; J. Mol. Biol., 2017; PubMed: 29273204; DOI: 10.1016/j.jmb.2017.12.012

実験手法

X-RAY DIFFRACTION (3.287 Å)