5CJ6
Crystal Structure of a Selective Androgen Receptor Modulator Bound to the Ligand Binding Domain of the Human Androgen Receptor
Summary for 5CJ6
Entry DOI | 10.2210/pdb5cj6/pdb |
Descriptor | Androgen receptor, small peptide, 2-chloro-4-{[(1R,2R)-2-hydroxy-2-methylcyclopentyl]amino}-3-methylbenzonitrile, ... (4 entities in total) |
Functional Keywords | androgen receptor, nuclear hormone receptor, signaling protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus: P10275 |
Total number of polymer chains | 2 |
Total formula weight | 34063.79 |
Authors | |
Primary citation | Saeed, A.,Vaught, G.M.,Gavardinas, K.,Matthews, D.,Green, J.E.,Losada, P.G.,Bullock, H.A.,Calvert, N.A.,Patel, N.J.,Sweetana, S.A.,Krishnan, V.,Henck, J.W.,Luz, J.G.,Wang, Y.,Jadhav, P. 2-Chloro-4-[[(1R,2R)-2-hydroxy-2-methyl-cyclopentyl]amino]-3-methyl-benzonitrile: A Transdermal Selective Androgen Receptor Modulator (SARM) for Muscle Atrophy. J.Med.Chem., 59:750-755, 2016 Cited by PubMed: 26683992DOI: 10.1021/acs.jmedchem.5b01168 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
Download full validation report