5CIL

Crystal Structure of non-neutralizing version of 4E10 (WDWD) with epitope bound

Summary for 5CIL

• Entry DOI: 10.2210/pdb5cil/pdb
• Related: 5CIN 5CIP
• Descriptor: FAB 4E10 HEAVY CHAIN, FAB 4E10 LIGHT CHAIN, Peptide from the MPER region of the ENV protein of HIV-1, ... (7 entities in total)
• Functional Keywords: broadly neutralizing antibody, recombinant fab, env-peptide, hiv-1, epitope, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 49198.73

Authors

Caaveiro, J.M.M.,Rujas, E.,Nieva, J.L.,Tsumoto, K. (deposition date: 2015-07-13, release date: 2015-09-23, Last modification date: 2023-11-08)

• Primary citation: Rujas, E.,Gulzar, N.,Morante, K.,Tsumoto, K.,Scott, J.K.,Nieva, J.L.,Caaveiro, J.M.M.; Structural and Thermodynamic Basis of Epitope Binding by Neutralizing and Nonneutralizing Forms of the Anti-HIV-1 Antibody 4E10; J.Virol., 89:11975-11989, 2015; PubMed: 26378169; DOI: 10.1128/JVI.01793-15

Experimental method

X-RAY DIFFRACTION (1.81 Å)