5CGP

Selective pharmacological inhibition of the CREB binding protein bromodomain regulates inflammatory cytokines in macrophages and RGS4 in neurons

5CGP の概要

• エントリーDOI: 10.2210/pdb5cgp/pdb
• 関連するPDBエントリー: 5CFW
• 分子名称: CREB-binding protein, 5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[2-(4-methoxyphenyl)ethyl]-1-[2-(morpholin-4-yl)ethyl]-1H-benzimidazole (3 entities in total)
• 機能のキーワード: inhibitor, complex, transcription-inhibitor complex, transcription/inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: Q92793
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14683.92

構造登録者

Chekler, E.L.,Jones, L.H. (登録日: 2015-07-09, 公開日: 2016-04-20, 最終更新日: 2023-09-27)

• 主引用文献: Chekler, E.L.,Pellegrino, J.A.,Lanz, T.A.,Denny, R.A.,Flick, A.C.,Coe, J.,Langille, J.,Basak, A.,Liu, S.,Stock, I.A.,Sahasrabudhe, P.,Bonin, P.D.,Lee, K.,Pletcher, M.T.,Jones, L.H.; Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities.; Chem.Biol., 22:1588-1596, 2015; PubMed: 26670081; DOI: 10.1016/j.chembiol.2015.10.013

実験手法

X-RAY DIFFRACTION (1.96 Å)