5CFW

Selective pharmacological inhibition of the CREB binding protein bromodomain regulates inflammatory cytokines in macrophages and RGS4 in neurons

Summary for 5CFW

Entry DOI	10.2210/pdb5cfw/pdb
Related	5CGP
Descriptor	Bromodomain-containing protein 4, 5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[2-(4-methoxyphenyl)ethyl]-1-[2-(morpholin-4-yl)ethyl]-1H-benzimidazole (3 entities in total)
Functional Keywords	inhibitor complex, transcription-inhibitor complex, transcription/inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: O60885
Total number of polymer chains	1
Total formula weight	15559.95
Authors	Chekler, E.L.,Jones, L.H. (deposition date: 2015-07-08, release date: 2016-04-20, Last modification date: 2023-09-27)
Primary citation	Chekler, E.L.,Pellegrino, J.A.,Lanz, T.A.,Denny, R.A.,Flick, A.C.,Coe, J.,Langille, J.,Basak, A.,Liu, S.,Stock, I.A.,Sahasrabudhe, P.,Bonin, P.D.,Lee, K.,Pletcher, M.T.,Jones, L.H. Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities. Chem.Biol., 22:1588-1596, 2015 Cited by PubMed: 26670081 DOI: 10.1016/j.chembiol.2015.10.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.15 Å)

Structure validation