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5CGP

Selective pharmacological inhibition of the CREB binding protein bromodomain regulates inflammatory cytokines in macrophages and RGS4 in neurons

Functional Information from GO Data
ChainGOidnamespacecontents
A0004402molecular_functionhistone acetyltransferase activity
A0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues12
Detailsbinding site for residue 53W A 4000
ChainResidue
APRO1110
APHE1177
AHOH4110
AHOH4127
AGLN1113
AVAL1115
ALEU1120
AILE1122
ATYR1125
AASN1168
AARG1173
AVAL1174

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. SlpFrqpvDpqllgipDYFdiVknpMdlstIkrkldtgq..Yqepwqyvddvwl.MfnNAwlY
ChainResidueDetails
ASER1108-TYR1167

222624

PDB entries from 2024-07-17

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