5CG6

Neutron crystal structure of human farnesyl pyrophosphate synthase in complex with risedronate and isopentenyl pyrophosphate

5CG6 の概要

• エントリーDOI: 10.2210/pdb5cg6/pdb
• 関連するPDBエントリー: 5cg5
• 分子名称: Farnesyl pyrophosphate synthase, MAGNESIUM ION, 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, ... (5 entities in total)
• 機能のキーワード: prenyl transferase, bisphosphonate, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P14324
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41632.97

構造登録者

Yokoyama, T.,Mizuguchi, M.,Ostermann, A.,Kusaka, K.,Niimura, N.,Schrader, T.E.,Tanaka, I. (登録日: 2015-07-09, 公開日: 2015-10-14, 最終更新日: 2024-04-03)

• 主引用文献: Yokoyama, T.,Mizuguchi, M.,Ostermann, A.,Kusaka, K.,Niimura, N.,Schrader, T.E.,Tanaka, I.; Protonation State and Hydration of Bisphosphonate Bound to Farnesyl Pyrophosphate Synthase; J.Med.Chem., 58:7549-7556, 2015; PubMed: 26314394; DOI: 10.1021/acs.jmedchem.5b01147

実験手法

NEUTRON DIFFRACTION (2.4 Å)
X-RAY DIFFRACTION (1.7 Å)