5CEN
Crystal structure of DLK (kinase domain)
Summary for 5CEN
Entry DOI | 10.2210/pdb5cen/pdb |
Related | 5CEO 5CEP 5CEQ |
Descriptor | Mitogen-activated protein kinase kinase kinase 12 (2 entities in total) |
Functional Keywords | kinase, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q12852 |
Total number of polymer chains | 1 |
Total formula weight | 34018.03 |
Authors | HARRIS, S.F.,YIN, J. (deposition date: 2015-07-07, release date: 2015-10-14, Last modification date: 2023-09-27) |
Primary citation | Patel, S.,Harris, S.F.,Gibbons, P.,Deshmukh, G.,Gustafson, A.,Kellar, T.,Lin, H.,Liu, X.,Liu, Y.,Liu, Y.,Ma, C.,Scearce-Levie, K.,Ghosh, A.S.,Shin, Y.G.,Solanoy, H.,Wang, J.,Wang, B.,Yin, J.,Siu, M.,Lewcock, J.W. Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12). J.Med.Chem., 58:8182-8199, 2015 Cited by PubMed: 26431428DOI: 10.1021/acs.jmedchem.5b01072 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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