5CDO

3.15A structure of QPT-1 with S.aureus DNA gyrase and DNA

Summary for 5CDO

• Entry DOI: 10.2210/pdb5cdo/pdb
• Descriptor: DNA gyrase subunit A, (2R,4S,4aS,5R)-6'-hydroxy-2,4-dimethyl-8-nitro-1,2,4,4a-tetrahydro-2'H,6H-spiro[1,4-oxazino[4,3-a]quinoline-5,5'-pyrimidine]-2',4'(3'H)-dione, DNA gyrase subunit B,DNA gyrase subunit B, ... (11 entities in total)
• Functional Keywords: type iia topoisomerase, antibacterial, inhibitor, isomerase
• Biological source: Staphylococcus aureus (strain N315); More
• Cellular location: Cytoplasm : Q99XG5
• Total number of polymer chains: 12
• Total formula weight: 330738.20

Authors

Bax, B.D.,Srikannathasan, V.,Chan, P.F. (deposition date: 2015-07-04, release date: 2015-12-16)

• Primary citation: Chan, P.F.,Srikannathasan, V.,Huang, J.,Cui, H.,Fosberry, A.P.,Gu, M.,Hann, M.M.,Hibbs, M.,Homes, P.,Ingraham, K.,Pizzollo, J.,Shen, C.,Shillings, A.J.,Spitzfaden, C.E.,Tanner, R.,Theobald, A.J.,Stavenger, R.A.,Bax, B.D.,Gwynn, M.N.; Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin.; Nat Commun, 6:10048-10048, 2015; PubMed: 26640131; DOI: 10.1038/ncomms10048

Experimental method

X-RAY DIFFRACTION (3.15 Å)