5CDM

2.5A structure of QPT-1 with S.aureus DNA gyrase and DNA

Summary for 5CDM

• Entry DOI: 10.2210/pdb5cdm/pdb
• Descriptor: DNA gyrase subunit B,DNA gyrase subunit B, THYMIDINE-5'-MONOPHOSPHATE, DNA gyrase subunit A, ... (11 entities in total)
• Functional Keywords: type iia topoisomerase, antibacterial, inhibitor, isomerase
• Biological source: Staphylococcus aureus; More
• Cellular location: Cytoplasm : P66937 Q99XG5
• Total number of polymer chains: 8
• Total formula weight: 165913.28

Authors

Bax, B.D.,Srikannathasan, V.,Chan, P.F. (deposition date: 2015-07-04, release date: 2015-12-16, Last modification date: 2024-01-10)

• Primary citation: Chan, P.F.,Srikannathasan, V.,Huang, J.,Cui, H.,Fosberry, A.P.,Gu, M.,Hann, M.M.,Hibbs, M.,Homes, P.,Ingraham, K.,Pizzollo, J.,Shen, C.,Shillings, A.J.,Spitzfaden, C.E.,Tanner, R.,Theobald, A.J.,Stavenger, R.A.,Bax, B.D.,Gwynn, M.N.; Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin.; Nat Commun, 6:10048-10048, 2015; PubMed: 26640131; DOI: 10.1038/ncomms10048

Experimental method

X-RAY DIFFRACTION (2.5 Å)