5CDM

2.5A structure of QPT-1 with S.aureus DNA gyrase and DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A	0005524	molecular_function	ATP binding
A	0006259	biological_process	DNA metabolic process
A	0006265	biological_process	DNA topological change
B	0003677	molecular_function	DNA binding
B	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
B	0005524	molecular_function	ATP binding
B	0006265	biological_process	DNA topological change
C	0003677	molecular_function	DNA binding
C	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
C	0005524	molecular_function	ATP binding
C	0006259	biological_process	DNA metabolic process
C	0006265	biological_process	DNA topological change
D	0003677	molecular_function	DNA binding
D	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
D	0005524	molecular_function	ATP binding
D	0006265	biological_process	DNA topological change

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MN B 1001

Chain	Residue
B	ASP508
B	ASP510
B	HOH1102
B	HOH1108
B	HOH1114
B	HOH1127

---

site_id	AC2
Number of Residues	4
Details	binding site for residue GOL B 1002

Chain	Residue
N	DG2013
B	ASN475
B	ASN476
B	GLU477

---

site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 A 501

Chain	Residue
A	ASN313
A	SER315
A	VAL316

---

site_id	AC4
Number of Residues	5
Details	binding site for residue NA A 502

Chain	Residue
A	TYR322
A	THR325
A	GLN328
A	HOH684
A	HOH689

---

site_id	AC5
Number of Residues	5
Details	binding site for residue GOL A 503

Chain	Residue
A	ARG47
A	ARG48
A	GLU156
A	PRO157
A	HOH632

---

site_id	AC6
Number of Residues	6
Details	binding site for residue MN D 701

Chain	Residue
D	ASP508
D	ASP510
D	HOH804
D	HOH808
D	HOH811
D	HOH816

---

site_id	AC7
Number of Residues	11
Details	binding site for residue 54Q I 2101

Chain	Residue
A	PTR123
A	HOH606
D	GLY436
D	ASP437
D	ARG458
D	GLY459
D	HOH802
F	DC8
I	DC2012
I	DG2013
N	DG2009

---

site_id	AC8
Number of Residues	4
Details	binding site for residue DT N 2101

Chain	Residue
A	SER240
A	SER330
C	ARG414
N	DT2019

---

site_id	AC9
Number of Residues	11
Details	binding site for residue 54Q N 2102

Chain	Residue
B	GLY436
B	ASP437
B	ARG458
B	GLY459
B	HOH1101
C	PTR123
E	DC8
I	DG2009
N	DC2012
N	DG2013
N	HOH2214

---

Functional Information from PROSITE/UniProt

site_id	PS00177
Number of Residues	9
Details	TOPOISOMERASE_II DNA topoisomerase II signature. LVEGDSAGG

Chain	Residue	Details
B	LEU433-GLY441

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	228
Details	Domain: {"description":"Toprim","evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Site: {"description":"Interaction with DNA","evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Active site: {"description":"O-(5'-phospho-DNA)-tyrosine intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_01897","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---