5CCV
Crystal structure of full-length NS5 from dengue virus type 3
5CCV の概要
エントリーDOI | 10.2210/pdb5ccv/pdb |
分子名称 | RNA-directed RNA polymerase NS5, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE (3 entities in total) |
機能のキーワード | methyltransferase, nonstructural protein, transferase |
由来する生物種 | Dengue virus type 3 (DENV-3) |
細胞内の位置 | Capsid protein C: Virion . Peptide pr: Secreted . Small envelope protein M: Virion membrane ; Multi-pass membrane protein . Envelope protein E: Virion membrane ; Multi-pass membrane protein . Non-structural protein 1: Secreted. Non-structural protein 2A: Host endoplasmic reticulum membrane ; Multi- pass membrane protein . Serine protease subunit NS2B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Multi- pass membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi- pass membrane protein . RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P27915 |
タンパク質・核酸の鎖数 | 8 |
化学式量合計 | 837241.70 |
構造登録者 | |
主引用文献 | Klema, V.J.,Ye, M.,Hindupur, A.,Teramoto, T.,Gottipati, K.,Padmanabhan, R.,Choi, K.H. Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface. Plos Pathog., 12:e1005451-e1005451, 2016 Cited by PubMed: 26895240DOI: 10.1371/journal.ppat.1005451 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (3.6 Å) |
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