5CCV

Crystal structure of full-length NS5 from dengue virus type 3

5CCV の概要

• エントリーDOI: 10.2210/pdb5ccv/pdb
• 分子名称: RNA-directed RNA polymerase NS5, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE (3 entities in total)
• 機能のキーワード: methyltransferase, nonstructural protein, transferase
• 由来する生物種: Dengue virus type 3 (DENV-3)
• 細胞内の位置: Capsid protein C: Virion . Peptide pr: Secreted . Small envelope protein M: Virion membrane ; Multi-pass membrane protein . Envelope protein E: Virion membrane ; Multi-pass membrane protein . Non-structural protein 1: Secreted. Non-structural protein 2A: Host endoplasmic reticulum membrane ; Multi- pass membrane protein . Serine protease subunit NS2B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Multi- pass membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi- pass membrane protein . RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P27915
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 837241.70

構造登録者

Klema, V.J.,Choi, K.H. (登録日: 2015-07-02, 公開日: 2016-02-03, 最終更新日: 2023-09-27)

• 主引用文献: Klema, V.J.,Ye, M.,Hindupur, A.,Teramoto, T.,Gottipati, K.,Padmanabhan, R.,Choi, K.H.; Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface.; Plos Pathog., 12:e1005451-e1005451, 2016; PubMed: 26895240; DOI: 10.1371/journal.ppat.1005451

実験手法

X-RAY DIFFRACTION (3.6 Å)