5CBR

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (S)-2-amino-3-(3,4-dichloro-5-(5-hydroxypyridin-3-yl)phenyl)propanoic acid at 2.0A resolution

5CBR の概要

• エントリーDOI: 10.2210/pdb5cbr/pdb
• 分子名称: Glutamate receptor 2,Glutamate receptor 2, 3,4-dichloro-5-(5-hydroxypyridin-3-yl)-L-phenylalanine, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: ampa receptor ligand-binding domain, glua2-s1s2j, antagonist, membrane protein
• 由来する生物種: Rattus norvegicus (Norway Rat); 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P19491
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30517.60

構造登録者

Frydenvang, K.,Kastrup, J.S. (登録日: 2015-07-01, 公開日: 2015-12-30, 最終更新日: 2024-01-10)

• 主引用文献: Szymanska, E.,Frydenvang, K.,Pickering, D.S.,Krintel, C.,Nielsen, B.,Kooshki, A.,Zachariassen, L.G.,Olsen, L.,Kastrup, J.S.,Johansen, T.N.; Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors.; J.Med.Chem., 59:448-461, 2016; PubMed: 26653877; DOI: 10.1021/acs.jmedchem.5b01666

実験手法

X-RAY DIFFRACTION (1.996 Å)