5CBA

3B4 in complex with CXCL13 - 3B4-CXCL13

Summary for 5CBA

Related5C2B
Descriptor3b4 heavy chain, 3b4 light chain, C-X-C motif chemokine 13, ... (6 entities in total)
Functional Keywordsanti-cxcl13, cxcl13, scfv, immune system
Biological sourceHomo sapiens (Human)
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Total number of polymer chains6
Total molecular weight75774.83
Authors
Tu, C.,Bard, J.,Mosyak, L. (deposition date: 2015-06-30, release date: 2015-11-04, Last modification date: 2018-11-14)
Primary citation
Tu, C.,Terraube, V.,Tam, A.S.,Stochaj, W.,Fennell, B.J.,Lin, L.,Stahl, M.,LaVallie, E.R.,Somers, W.,Finlay, W.J.,Mosyak, L.,Bard, J.,Cunningham, O.
A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv).
J. Biol. Chem., 291:1267-1276, 2016
PubMed: 26515064 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M115.688010
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.23940 6.6% 4.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution