5C8W
PKG II's Amino Terminal Cyclic Nucleotide Binding Domain (CNB-A) in a complex with cGMP
Summary for 5C8W
Entry DOI | 10.2210/pdb5c8w/pdb |
Descriptor | cGMP-dependent protein kinase 2, MALONIC ACID, CYCLIC GUANOSINE MONOPHOSPHATE, ... (5 entities in total) |
Functional Keywords | binding sites, cyclic amp, cyclic gmp, cyclic gmp-dependent protein kinase type ii, mutagenesis, site-directed, protein binding, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Apical cell membrane ; Lipid-anchor : Q13237 |
Total number of polymer chains | 6 |
Total formula weight | 102330.27 |
Authors | Campbell, J.C.,Reger, A.S.,Huang, G.Y.,Sankaran, B.,Kim, J.J.,Kim, C.W. (deposition date: 2015-06-26, release date: 2016-01-20, Last modification date: 2024-03-06) |
Primary citation | Campbell, J.C.,Kim, J.J.,Li, K.Y.,Huang, G.Y.,Reger, A.S.,Matsuda, S.,Sankaran, B.,Link, T.M.,Yuasa, K.,Ladbury, J.E.,Casteel, D.E.,Kim, C. Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II. J.Biol.Chem., 291:5623-5633, 2016 Cited by PubMed: 26769964DOI: 10.1074/jbc.M115.691303 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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