5C5A
Crystal Structure of HDM2 in complex with Nutlin-3a
Summary for 5C5A
Entry DOI | 10.2210/pdb5c5a/pdb |
Descriptor | E3 ubiquitin-protein ligase Mdm2, 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, SULFATE ION, ... (6 entities in total) |
Functional Keywords | drug design, hdm2, complex structure, ligase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus, nucleoplasm: Q00987 |
Total number of polymer chains | 2 |
Total formula weight | 23474.90 |
Authors | Orts, J.,Waelti, M.A.,Marsh, M.,Vera, L.,Gossert, A.D.,Guentert, P.,Riek, R. (deposition date: 2015-06-19, release date: 2016-06-29, Last modification date: 2024-01-10) |
Primary citation | Orts, J.,Waelti, M.A.,Marsh, M.,Vera, L.,Gossert, A.D.,Guentert, P.,Riek, R. NMR Molecular Replacement, NMR2 To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.146 Å) |
Structure validation
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