5C51
Probing the Structural and Molecular Basis of Nucleotide Selectivity by Human Mitochondrial DNA Polymerase gamma
Summary for 5C51
Entry DOI | 10.2210/pdb5c51/pdb |
Related | 5C52 |
Descriptor | DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, DNA (5'-D(*(AD)P*AP*AP*AP*CP*GP*AP*GP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*GP*TP*AP*C)-3'), ... (6 entities in total) |
Functional Keywords | nucleoside reverse transcriptase inhibitors (nrtis), hiv rt, human mitochondrial dna polymerase, mitochondrial toxicity, drug efficacy and toxicity, transferase-dna complex, transferase/dna |
Biological source | Homo sapiens (Human) More |
Cellular location | Mitochondrion : P54098 Q9UHN1 |
Total number of polymer chains | 5 |
Total formula weight | 261003.65 |
Authors | Sohl, C.D.,Szymanski, M.R.,Mislak, A.C.,Shumate, C.K.,Amiralaei, S.,Schinazi, R.F.,Anderson, K.S.,Whitney, Y.Y. (deposition date: 2015-06-19, release date: 2016-05-11, Last modification date: 2016-05-18) |
Primary citation | Sohl, C.D.,Szymanski, M.R.,Mislak, A.C.,Shumate, C.K.,Amiralaei, S.,Schinazi, R.F.,Anderson, K.S.,Yin, Y.W. Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase gamma. Proc.Natl.Acad.Sci.USA, 112:8596-8601, 2015 Cited by PubMed: 26124101DOI: 10.1073/pnas.1421733112 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.426 Å) |
Structure validation
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