5C23

Parkin (S65DUblR0RBR)

Summary for 5C23

Entry DOI	10.2210/pdb5c23/pdb
Descriptor	E3 ubiquitin-protein ligase parkin, ZINC ION, GLYCEROL, ... (6 entities in total)
Functional Keywords	e3 ligase2, ligase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm, cytosol : O60260
Total number of polymer chains	2
Total formula weight	93044.61
Authors	Kumar, A.,Aguirre, J.D.,Condos, T.E.C.,Martinez-Torres, R.J.,Chaugule, V.K.,Toth, R.,Sundaramoorthy, R.,Mercier, P.,Knebel, A.,Spratt, D.E.,Barber, K.R.,Shaw, G.S.,Walden, H. (deposition date: 2015-06-15, release date: 2015-07-29, Last modification date: 2024-01-10)
Primary citation	Kumar, A.,Aguirre, J.D.,Condos, T.E.,Martinez-Torres, R.J.,Chaugule, V.K.,Toth, R.,Sundaramoorthy, R.,Mercier, P.,Knebel, A.,Spratt, D.E.,Barber, K.R.,Shaw, G.S.,Walden, H. Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis. Embo J., 34:2506-2521, 2015 Cited by PubMed: 26254304 DOI: 10.15252/embj.201592337 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.37 Å)

Structure validation