5C23
Parkin (S65DUblR0RBR)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0008270 | molecular_function | zinc ion binding |
| B | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0008270 | molecular_function | zinc ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 501 |
| Chain | Residue |
| A | CYS150 |
| A | CYS154 |
| A | CYS212 |
| A | HIS215 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 502 |
| Chain | Residue |
| A | CYS166 |
| A | CYS169 |
| A | CYS196 |
| A | CYS201 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 503 |
| Chain | Residue |
| A | CYS241 |
| A | CYS260 |
| A | CYS263 |
| A | CYS238 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 504 |
| Chain | Residue |
| A | CYS253 |
| A | HIS257 |
| A | CYS289 |
| A | CYS293 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue ZN A 505 |
| Chain | Residue |
| A | CYS332 |
| A | CYS337 |
| A | CYS352 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 506 |
| Chain | Residue |
| A | CYS365 |
| A | CYS368 |
| A | HIS373 |
| A | CYS377 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 507 |
| Chain | Residue |
| A | CYS418 |
| A | CYS421 |
| A | CYS436 |
| A | CYS441 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 508 |
| Chain | Residue |
| A | CYS446 |
| A | CYS449 |
| A | CYS457 |
| A | HIS461 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 509 |
| Chain | Residue |
| A | VAL186 |
| A | LEU187 |
| A | GLU207 |
| A | PHE208 |
| A | HOH623 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 510 |
| Chain | Residue |
| A | HIS227 |
| A | ALA230 |
| A | GLN252 |
| A | ARG256 |
| A | TRP403 |
| A | GLU404 |
| A | VAL465 |
| A | HOH607 |
| site_id | AD2 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 511 |
| Chain | Residue |
| A | GLN57 |
| A | ASN58 |
| A | LYS161 |
| A | ARG163 |
| A | LYS211 |
| A | THR217 |
| A | ARG455 |
| A | HOH614 |
| A | HOH621 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 512 |
| Chain | Residue |
| A | LYS416 |
| A | TRP447 |
| A | ASN448 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 513 |
| Chain | Residue |
| A | PHE146 |
| A | TYR147 |
| A | TRP183 |
| A | LEU226 |
| A | ILE229 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 501 |
| Chain | Residue |
| B | CYS150 |
| B | CYS154 |
| B | CYS212 |
| B | HIS215 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 502 |
| Chain | Residue |
| B | CYS166 |
| B | CYS169 |
| B | CYS196 |
| B | CYS201 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 503 |
| Chain | Residue |
| B | CYS238 |
| B | CYS241 |
| B | CYS260 |
| B | CYS263 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 504 |
| Chain | Residue |
| B | CYS253 |
| B | HIS257 |
| B | CYS289 |
| B | CYS293 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue ZN B 505 |
| Chain | Residue |
| B | CYS332 |
| B | CYS337 |
| B | CYS352 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 506 |
| Chain | Residue |
| B | CYS365 |
| B | CYS368 |
| B | HIS373 |
| B | CYS377 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 507 |
| Chain | Residue |
| B | CYS418 |
| B | CYS421 |
| B | CYS436 |
| B | CYS441 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 508 |
| Chain | Residue |
| B | CYS446 |
| B | CYS449 |
| B | CYS457 |
| B | HIS461 |
| site_id | AE4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 509 |
| Chain | Residue |
| B | VAL186 |
| B | GLU207 |
| B | PHE208 |
| B | HOH602 |
| B | HOH623 |
| site_id | AE5 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 510 |
| Chain | Residue |
| B | GLN252 |
| B | ARG256 |
| B | GLU404 |
| B | VAL465 |
| B | HOH619 |
| B | HIS227 |
| B | ALA230 |
| site_id | AE6 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 B 511 |
| Chain | Residue |
| B | ASN58 |
| B | LYS161 |
| B | ARG163 |
| B | LYS211 |
| B | THR217 |
| B | ARG455 |
| B | HOH613 |
| B | HOH618 |
| B | HOH660 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 150 |
| Details | Domain: {"description":"Ubiquitin-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 110 |
| Details | Zinc finger: {"description":"RING-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 62 |
| Details | Zinc finger: {"description":"RING-type 2; atypical","evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 68 |
| Details | Region: {"description":"SYT11 binding 1","evidences":[{"source":"PubMed","id":"12925569","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 72 |
| Details | Region: {"description":"SYT11 binding 2","evidences":[{"source":"PubMed","id":"12925569","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23770917","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 22 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23770917","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PINK1","evidences":[{"source":"PubMed","id":"18957282","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23754282","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24660806","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24784582","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25474007","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by PINK1","evidences":[{"source":"PubMed","id":"18957282","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18957282","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 6 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15)","evidences":[{"source":"PubMed","id":"27534820","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
