5BYA

Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP and 1,5-(PCP)2-IP4

5BYA の概要

• エントリーDOI: 10.2210/pdb5bya/pdb
• 関連するPDBエントリー: 5BYB
• 分子名称: Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2, ADENOSINE-5'-DIPHOSPHATE, {[(1R,3S,4S,5R,6S)-2,4,5,6-tetrakis(phosphonooxy)cyclohexane-1,3-diyl]bis[oxy(hydroxyphosphoryl)methanediyl]}bis(phosphonic acid), ... (7 entities in total)
• 機能のキーワード: methylenebisphosphonate, phosphonoacetate, non-hydrolyzable, pyrophosphate mimics, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm, cytosol : O43314
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39480.18

構造登録者

Wang, H.,Shears, S.B. (登録日: 2015-06-10, 公開日: 2015-07-22, 最終更新日: 2023-09-27)

主引用文献

Riley, A.M.,Wang, H.,Shears, S.B.,L Potter, B.V.
Synthetic tools for studying the chemical biology of InsP8.
Chem.Commun.(Camb.), 51:12605-12608, 2015

PubMed Abstract: To synthesise stabilised mimics of InsP8, the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural and biochemical analyses of their interactions with enzymes of InsP8 metabolism.

PubMed: 26153667
DOI: 10.1039/c5cc05017k

実験手法

X-RAY DIFFRACTION (1.9 Å)