5BY6
Crystal structure of Trichinella spiralis thymidylate synthase complexed with dUMP
Replaces: 4G9USummary for 5BY6
Entry DOI | 10.2210/pdb5by6/pdb |
Descriptor | Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... (5 entities in total) |
Functional Keywords | trichinella spiralis, parasitic nematode, protein-ligand complex, methyltransferase, transferase |
Biological source | Trichinella spiralis (Trichina worm) |
Total number of polymer chains | 4 |
Total formula weight | 144301.48 |
Authors | Dowiercial, A.,Jarmula, A.,Rypniewski, W.,Fraczyk, T.,Wilk, P.,Rode, W. (deposition date: 2015-06-10, release date: 2015-06-17, Last modification date: 2024-01-10) |
Primary citation | Jarmula, A.,Wilk, P.,Maj, P.,Ludwiczak, J.,Dowiercial, A.,Banaszak, K.,Rypniewski, W.,Ciesla, J.,Dabrowska, M.,Fraczyk, T.,Bronowska, A.K.,Jakowiecki, J.,Filipek, S.,Rode, W. Crystal structures of nematode (parasitic T. spiralis and free living C. elegans), compared to mammalian, thymidylate synthases (TS). Molecular docking and molecular dynamics simulations in search for nematode-specific inhibitors of TS. J. Mol. Graph. Model., 77:33-50, 2017 Cited by PubMed: 28826032DOI: 10.1016/j.jmgm.2017.08.008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report