5BXO

Human Tankyrase-2 in Complex with Macrocyclised Extended Peptide cp4n2m3

Summary for 5BXO

Entry DOI	10.2210/pdb5bxo/pdb
Descriptor	Tankyrase-2, SULFATE ION, DIMETHYL SULFOXIDE, ... (6 entities in total)
Functional Keywords	stapled peptide, protein-protein interaction, ankyrin-repeat domain, tankyrase, transferase
Biological source	Homo sapiens (Human) More
Cellular location	Cytoplasm: Q9H2K2 Q9H2K2
Total number of polymer chains	4
Total formula weight	38352.89
Authors	Xu, W.,Fischer, G.,Hyvonen, M.,Itzhaki, L. (deposition date: 2015-06-09, release date: 2016-06-29, Last modification date: 2023-03-29)
Primary citation	Xu, W.,Lau, Y.H.,Fischer, G.,Tan, Y.S.,Chattopadhyay, A.,de la Roche, M.,Hyvonen, M.,Verma, C.,Spring, D.R.,Itzhaki, L.S. Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase. J.Am.Chem.Soc., 139:2245-2256, 2017 Cited by PubMed: 28084734 DOI: 10.1021/jacs.6b10234 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.334 Å)

Structure validation