5BWZ

Crystal structure of S39E HDAC8 in complex with Droxinostat

Summary for 5BWZ

Entry DOI	10.2210/pdb5bwz/pdb
Descriptor	Histone deacetylase 8, ZINC ION, POTASSIUM ION, ... (6 entities in total)
Functional Keywords	arginase/deacetylase fold, hydrolase, histone deacetylase, enzyme inhibitor-complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	87414.73
Authors	Decroos, C.,Christianson, D.W. (deposition date: 2015-06-08, release date: 2016-06-08, Last modification date: 2023-09-27)
Primary citation	Welker Leng, K.R.,Castaneda, C.A.,Decroos, C.,Islam, B.,Haider, S.M.,Christianson, D.W.,Fierke, C.A. Phosphorylation of Histone Deacetylase 8: Structural and Mechanistic Analysis of the Phosphomimetic S39E Mutant. Biochemistry, 58:4480-4493, 2019 Cited by PubMed: 31633931 DOI: 10.1021/acs.biochem.9b00653 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.59 Å)

Structure validation