5BWZ

Crystal structure of S39E HDAC8 in complex with Droxinostat

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000118	cellular_component	histone deacetylase complex
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000228	cellular_component	nuclear chromosome
A	0004407	molecular_function	histone deacetylase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0006325	biological_process	chromatin organization
A	0007064	biological_process	mitotic sister chromatid cohesion
A	0016787	molecular_function	hydrolase activity
A	0030544	molecular_function	Hsp70 protein binding
A	0031397	biological_process	negative regulation of protein ubiquitination
A	0031507	biological_process	heterochromatin formation
A	0031647	biological_process	regulation of protein stability
A	0032204	biological_process	regulation of telomere maintenance
A	0033558	molecular_function	protein lysine deacetylase activity
A	0046872	molecular_function	metal ion binding
A	0051879	molecular_function	Hsp90 protein binding
A	0140297	molecular_function	DNA-binding transcription factor binding
A	0141221	molecular_function	histone deacetylase activity, hydrolytic mechanism
A	0160008	molecular_function	protein decrotonylase activity
A	0160009	molecular_function	histone decrotonylase activity
B	0000118	cellular_component	histone deacetylase complex
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000228	cellular_component	nuclear chromosome
B	0004407	molecular_function	histone deacetylase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0005737	cellular_component	cytoplasm
B	0006325	biological_process	chromatin organization
B	0007064	biological_process	mitotic sister chromatid cohesion
B	0016787	molecular_function	hydrolase activity
B	0030544	molecular_function	Hsp70 protein binding
B	0031397	biological_process	negative regulation of protein ubiquitination
B	0031507	biological_process	heterochromatin formation
B	0031647	biological_process	regulation of protein stability
B	0032204	biological_process	regulation of telomere maintenance
B	0033558	molecular_function	protein lysine deacetylase activity
B	0046872	molecular_function	metal ion binding
B	0051879	molecular_function	Hsp90 protein binding
B	0140297	molecular_function	DNA-binding transcription factor binding
B	0141221	molecular_function	histone deacetylase activity, hydrolytic mechanism
B	0160008	molecular_function	protein decrotonylase activity
B	0160009	molecular_function	histone decrotonylase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"19053282","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19053282","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17721440","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15242608","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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