5BVJ
The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta
Summary for 5BVJ
Entry DOI | 10.2210/pdb5bvj/pdb |
Descriptor | canakinumab Fab light-chain, canakinumab Fab heavy-chain (3 entities in total) |
Functional Keywords | immunoglobulin, fab, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 190243.84 |
Authors | Rondeau, J.M. (deposition date: 2015-06-05, release date: 2015-09-02, Last modification date: 2020-03-11) |
Primary citation | Rondeau, J.M.,Ramage, P.,Zurini, M.,Gram, H. The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1 beta. Mabs, 7:1151-1160, 2015 Cited by PubMed: 26284424DOI: 10.1080/19420862.2015.1081323 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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