5BVE

Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase

Summary for 5BVE

• Entry DOI: 10.2210/pdb5bve/pdb
• Related: 5BVD 5BVF
• Descriptor: Mitogen-activated protein kinase 1, 2-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-8-[2-(tetrahydro-2H-pyran-4-ylamino)pyrimidin-4-yl]-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-a][1,4]diazepin-1-one, SULFATE ION, ... (4 entities in total)
• Functional Keywords: inhibitor, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm, cytoskeleton, spindle : P28482
• Total number of polymer chains: 1
• Total formula weight: 42333.85

Authors

Ma, X.,Steven, S. (deposition date: 2015-06-05, release date: 2015-09-09, Last modification date: 2023-09-27)

Primary citation

Bagdanoff, J.T.,Jain, R.,Han, W.,Zhu, S.,Madiera, A.M.,Lee, P.S.,Ma, X.,Poon, D.
Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase.
Bioorg.Med.Chem.Lett., 25:3788-3792, 2015

PubMed Abstract: A series of structure based drug design hypotheses and focused screening efforts led to the identification of tetrahydropyrrolo-diazepenones with striking potency against ERK2 kinase. The role of fluorination in mitigating microsomal clearance was systematically explored. Ultimately, it was found that fluorination of a cyclopentanol substructure provided significant improvement in both potency and human metabolic stability.

PubMed: 26259804
DOI: 10.1016/j.bmcl.2015.07.091

Experimental method

X-RAY DIFFRACTION (2 Å)