5BVE
Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Mitogen-activated protein kinase 1 | polymer | 361 | 41467.6 | 1 | UniProt (P28482) Pfam (PF00069) In PDB | Homo sapiens (Human) | MAPK 1,ERT1,Extracellular signal-regulated kinase 2,ERK-2,MAP kinase isoform p42,p42-MAPK,Mitogen-activated protein kinase 2,MAPK 2 |
| 2 | A | 2-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-8-[2-(tetrahydro-2H-pyran-4-ylamino)pyrimidin-4-yl]-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-a][1,4]diazepin-1-one | non-polymer | 482.0 | 1 | Chemie (4VG) | |||
| 3 | A | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 264 | Chemie (HOH) |
Sequence modifications
A: 0 - 358 (UniProt: P28482)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Pro -1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41467.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 866.2 | |
| All* | Total formula weight | 42333.9 |
