5BUU

Crystal structure of the GluA2 ligand-binding domain (L483Y-N754S) in complex with glutamate and BPAM-321 at 2.07 A resolution

5BUU の概要

• エントリーDOI: 10.2210/pdb5buu/pdb
• 関連するPDBエントリー: 3il1 4n07
• 分子名称: Glutamate receptor 2,Glutamate receptor 2, (3R)-7-chloro-2,3,4-trimethyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, GLUTAMIC ACID, ... (6 entities in total)
• 機能のキーワード: ampa receptor ligand-binding domain, glua2 l483y-n754s, bpam-321 positive allosteric modulation, membrane protein
• 由来する生物種: Rattus norvegicus (Norway Rat); 詳細
• 細胞内の位置: Cell membrane ; Multi-pass membrane protein : P19491
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 60095.75

構造登録者

Larsen, A.P.,Tapken, D.,Frydenvang, K.,Kastrup, J.S. (登録日: 2015-06-04, 公開日: 2016-02-17, 最終更新日: 2024-01-10)

• 主引用文献: Larsen, A.P.,Francotte, P.,Frydenvang, K.,Tapken, D.,Goffin, E.,Fraikin, P.,Caignard, D.H.,Lestage, P.,Danober, L.,Pirotte, B.,Kastrup, J.S.; Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors.; Acs Chem Neurosci, 7:378-390, 2016; PubMed: 26771108; DOI: 10.1021/acschemneuro.5b00318

実験手法

X-RAY DIFFRACTION (2.07 Å)