5BT2

MeCP2 MBD domain (A140V) in complex with methylated DNA

Summary for 5BT2

• Entry DOI: 10.2210/pdb5bt2/pdb
• Descriptor: Methyl-CpG-binding protein 2, DNA (5'-D(*TP*CP*TP*GP*GP*AP*AP*(5CM)P*GP*GP*AP*AP*TP*TP*CP*TP*TP*CP*TP*A)-3'), DNA (5'-D(*AP*TP*AP*GP*AP*AP*GP*AP*AP*TP*TP*CP*(5CM)P*GP*TP*TP*CP*CP*AP*G)-3'), ... (4 entities in total)
• Functional Keywords: a/t run, mecp2, hydration spine, methylated dna, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 23449.56

Authors

Ho, K.L.,Chia, J.Y.,Tan, W.S.,Ng, C.L.,Hu, N.J.,Foo, H.L. (deposition date: 2015-06-02, release date: 2016-08-17, Last modification date: 2023-11-08)

• Primary citation: Chia, J.Y.,Tan, W.S.,Ng, C.L.,Hu, N.J.,Foo, H.L.,Ho, K.L.; A/T Run Geometry of B-form DNA Is Independent of Bound Methyl-CpG Binding Domain, Cytosine Methylation and Flanking Sequence.; Sci Rep, 6:31210-31210, 2016; PubMed: 27502833; DOI: 10.1038/srep31210

Experimental method

X-RAY DIFFRACTION (2.2 Å)