5BT2

MeCP2 MBD domain (A140V) in complex with methylated DNA

5BT2 の概要

• エントリーDOI: 10.2210/pdb5bt2/pdb
• 分子名称: Methyl-CpG-binding protein 2, DNA (5'-D(*TP*CP*TP*GP*GP*AP*AP*(5CM)P*GP*GP*AP*AP*TP*TP*CP*TP*TP*CP*TP*A)-3'), DNA (5'-D(*AP*TP*AP*GP*AP*AP*GP*AP*AP*TP*TP*CP*(5CM)P*GP*TP*TP*CP*CP*AP*G)-3'), ... (4 entities in total)
• 機能のキーワード: a/t run, mecp2, hydration spine, methylated dna, dna binding protein-dna complex, dna binding protein/dna
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 23449.56

構造登録者

Ho, K.L.,Chia, J.Y.,Tan, W.S.,Ng, C.L.,Hu, N.J.,Foo, H.L. (登録日: 2015-06-02, 公開日: 2016-08-17, 最終更新日: 2023-11-08)

• 主引用文献: Chia, J.Y.,Tan, W.S.,Ng, C.L.,Hu, N.J.,Foo, H.L.,Ho, K.L.; A/T Run Geometry of B-form DNA Is Independent of Bound Methyl-CpG Binding Domain, Cytosine Methylation and Flanking Sequence.; Sci Rep, 6:31210-31210, 2016; PubMed: 27502833; DOI: 10.1038/srep31210

実験手法

X-RAY DIFFRACTION (2.2 Å)