5BRO

Crystal structure of modified HexB (modB)

Summary for 5BRO

• Entry DOI: 10.2210/pdb5bro/pdb
• Descriptor: Beta-hexosaminidase subunit beta, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... (5 entities in total)
• Functional Keywords: therapeutic enzyme, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 59726.36

Authors

Kitakaze, K.,Maita, N.,Itoh, K. (deposition date: 2015-06-01, release date: 2016-05-04, Last modification date: 2020-07-29)

• Primary citation: Kitakaze, K.,Mizutani, Y.,Sugiyama, E.,Tasaki, C.,Tsuji, D.,Maita, N.,Hirokawa, T.,Asanuma, D.,Kamiya, M.,Sato, K.,Setou, M.,Urano, Y.,Togawa, T.,Otaka, A.,Sakuraba, H.,Itoh, K.; Protease-resistant modified human beta-hexosaminidase B ameliorates symptoms in GM2 gangliosidosis model.; J.Clin.Invest., 126:1691-1703, 2016; PubMed: 27018595; DOI: 10.1172/JCI85300

Experimental method

X-RAY DIFFRACTION (2.4 Å)